Radiotherapy Complements Immune Checkpoint Blockade
Shin Foong Ngiow, Grant A McArthur, Mark J Smyth
Cancer Cell | CELL PRESS | Published : 2015
Adaptive immune resistance ablates effective anti-tumor immune responses. In a recent issue of Nature, Victor and colleagues describe that anti-PD-L1 combats adaptive immune resistance upon localized radiation plus anti-CTLA-4 therapy. The superior activity of radiation and dual immune checkpoint blockade is mediated by non-redundant immune mechanisms in cancer.