Journal article

Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer

Inge C Van Gool, Ellen Stelloo, Remi A Nout, Hans W Nijman, Richard J Edmondson, David N Church, Helen J MacKay, Alexandra Leary, Melanie E Powell, Linda Mileshkin, Carien L Creutzberg, Vincent THBM Smit, Tjalling Bosse



Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear. To evaluate this, its frequency, and the relationship of L1CAM with the established endometrial cancer biomarker p53, we analyzed the expression of both markers by immunohistochemistry in a pilot series of 116 endometrial cancers (86 endometrioid, 30 non-endometrioid subtype) with high-risk features (such as high tumor grade and deep myometrial invasion) and correlated results with clinical outcome. We used The ..

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University of Melbourne Researchers


Awarded by Dutch Cancer Society

Awarded by Academy of Medical Sciences (AMS)

Awarded by National Institute for Health Research

Funding Acknowledgements

This work was supported by the Dutch Cancer Society (KWF-UL2012-5719; to ICvG, ES, RAN, CLC, VTHBMS, and TB). DNC was funded by a Health Foundation/Academy of Medical Sciences Clinician Scientist Fellowship. We acknowledge all clinicians, technicians, scientists, and pathologists involved in the collaborating centers within the participating groups in the TransPORTEC consortium.