Journal article

Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer

Inge C Van Gool, Ellen Stelloo, Remi A Nout, Hans W Nijman, Richard J Edmondson, David N Church, Helen J MacKay, Alexandra Leary, Melanie E Powell, Linda Mileshkin, Carien L Creutzberg, Vincent THBM Smit, Tjalling Bosse



Studies in early-stage, predominantly low- and intermediate-risk endometrial cancer have demonstrated that L1 cell adhesion molecule (L1CAM) overexpression identifies patients at increased risk of recurrence, yet its prognostic significance in high-risk endometrial cancer is unclear. To evaluate this, its frequency, and the relationship of L1CAM with the established endometrial cancer biomarker p53, we analyzed the expression of both markers by immunohistochemistry in a pilot series of 116 endometrial cancers (86 endometrioid, 30 non-endometrioid subtype) with high-risk features (such as high tumor grade and deep myometrial invasion) and correlated results with clinical outcome. We used The ..

View full abstract

University of Melbourne Researchers