Journal article

The growth rate of early DWI lesions is highly variable and associated with penumbral salvage and clinical outcomes following endovascular reperfusion

Hayley M Wheeler, Michael Mlynash, Manabu Inoue, Aaryani Tipirnini, John Liggins, Roland Bammer, Maarten G Lansberg, Stephanie Kemp, Greg Zaharchuk, Matus Straka, Gregory W Albers

INTERNATIONAL JOURNAL OF STROKE | SAGE PUBLICATIONS LTD | Published : 2015

Abstract

BACKGROUND: The degree of variability in the rate of early diffusion-weighted imaging expansion in acute stroke has not been well characterized. AIM: We hypothesized that patients with slowly expanding diffusion-weighted imaging lesions would have more penumbral salvage and better clinical outcomes following endovascular reperfusion than patients with rapidly expanding diffusion-weighted imaging lesions. METHODS: In the first part of this substudy of DEFUSE 2, growth curves were constructed for patients with >90% reperfusion and 50% reduction in perfusion-weighted imaging after endovascular therapy) were categorized into tertiles according to their initial diffusion-weighted imaging growth r..

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University of Melbourne Researchers

Grants

Awarded by National Institute for Neurological Disorders and Stroke (NINDS)


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE


Funding Acknowledgements

Funding: The study was funded by grants from the National Institute for Neurological Disorders and Stroke (NINDS) [R01 NS03932505 (G. Albers), K23 NS051372 (M. Lansberg), and the Stanford Medical Scholars Fellowship Program.