Journal article
Progression-free and overall survival in ALK-Positive NSCLC patients treated with sequential Crizotinib and Ceritinib
JF Gainor, DSW Tan, T De Pas, BJ Solomon, A Ahmad, C Lazzari, F De Marinis, G Spitaleri, K Schultz, L Friboulet, BY Yeap, JA Engelman, AT Shaw
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2015
Abstract
Purpose: Anaplastic lymphoma kinase (ALK) rearrangements are important therapeutic targets in non-small cell lung cancer (NSCLC) that confer sensitivity to the ALK inhibitors crizotinib and ceritinib. To determine the outcome of sequential treatment with crizotinb and ceritinib, we retrospectively evaluated a cohort of ALK-positive patients treated with both agents. Experimental Design: We identified 73 ALK-positive NSCLC patients treated with crizotinib followed by ceritinib at four institutions. Medical records were reviewed to determine overall survival (OS) and progression-free survival (PFS) on crizotinib and ceritinib. Results: Among 73 ALK-positive patients, the median PFS (mPFS) on c..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by grants from the U.S. National Institutes of Health 5R01CA164273, 5P50CA090578-10, and C06CA059267.