Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries
Nicola Kahlberg, Cheng Xue Qin, Jarryd Anthonisz, Edwina Jap, Hooi Hooi Ng, Maria Jelinic, Laura J Parry, Barbara K Kemp-Harper, Rebecca H Ritchie, Chen Huei Leo
PHARMACOLOGICAL RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016
Increased vascular stiffness and reduced endothelial nitric oxide (NO) bioavailability are characteristic of diabetes. Whether these are evident at a more moderate levels of hyperglycaemia has not been investigated. The objectives of this study were to examine the association between the level of glycaemia and resistance vasculature phenotype, incorporating both arterial stiffness and endothelial function. Diabetes was induced in male Sprague Dawley rats with streptozotocin (STZ; 55mg/kg i.v.) and followed for 8 weeks. One week post STZ, diabetic rats were allocated to either moderate (∼20mM blood glucose, 6-7U/insulins.c. daily) or severe hyperglycaemia (∼30mM blood glucose, 1-2U/insulins.c..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported in part by both the National Health and Medical Research Council (NHMRC) of Australia, including APP1045140 (to R.H.R), APP1064845 (to L.J.P) and the Victorian Government's Operational Infrastructure Support Program. RHR is a NHMRC Senior Research Fellow (APP1059960). N.K. received a Melbourne Research Scholarship. M.J received an Australian Postgraduate Award and H.H.N received a Melbourne International Fee Remission Scholarship and a Melbourne International Research Scholarship. We also thank Ms Kelly O'Sullivan and Ms Sarah Marshall for their technical assistance in this study.