Journal article
Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore
M Monif, CA Reid, KL Powell, KJ Drummond, TJ O'Brien, DA Williams
Journal of Neuroinflammation | BIOMED CENTRAL LTD | Published : 2016
Abstract
Background: Enhanced expression of the purinergic P2X7 receptor (P2X7R) occurs in several neuroinflammatory conditions where increased microglial activation is a co-existing feature. P2X7 receptors can function either as a cation channel or, upon continued stimulation, a large pore. P2X7R-over-expression alone is sufficient to drive microglial activation and proliferation in a process that is P2X7R pore dependent, although the biological signaling pathway through which this occurs remains unclear. Once activated, microglia are known to release a number of bioactive substances that include the proinflammatory cytokine interleukin-1β (IL-1β). Previous studies have linked P2X7R stimulation to t..
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Awarded by Australian Research Council
Funding Acknowledgements
Our study was funded by the Australian Research Council (ARC; application number DP0770955 DA Williams). In addition, a small grant was received from Royal Melbourne Hospital Watt-Geyer Oncology - Brain Cancer Research Award through Department of Neurology, Royal Melbourne Hospital (2015; Monif et al.). The funding bodies played no role in design of the study, collection, analysis, or interpretation of the data or in writing the manuscript.