Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel

Nicholas Lachlan Opie; Nicole R van der Nagel; Sam E John; Kirstan Vessey; Gil S Rind; Stephen M Ronayne; Erica L Fletcher; Clive N May; Terence J O'Brien; Thomas J Oxley

Journal article

Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel

Nicholas Lachlan Opie, Nicole R van der Nagel, Sam E John, Kirstan Vessey, Gil S Rind, Stephen M Ronayne, Erica L Fletcher, Clive N May, Terence J O'Brien, Thomas J Oxley

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Published : 2017

DOI: 10.1109/TBME.2016.2552226

Abstract

OBJECTIVE: Recently, we reported the development of a stent-mounted electrode array (Stentrode) capable of chronically recording neural signals from within a blood vessel with high fidelity. Preliminary data suggested incorporation of the Stentrode into the blood vessel wall was associated with improved recording sensitivity. We now investigate neointimal incorporation of the Stentrode, implanted in a cohort of sheep for up to 190 days. METHODS: Micro-CT, obtained from the Imaging and Medical Beamline at the Australian Synchrotron, and histomorphometic techniques developed specifically for evaluation of cerebral vasculature implanted with a stent-electrode array were compared as measures to ..

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University of Melbourne Researchers

Nicholas Opie Author Medicine - Royal Melbourne Hospital

Thomas Oxley Author Medicine - Royal Melbourne Hospital

Sam John Author Biomedical Engineering

Clive May Author Biochemistry and Pharmacology

Stephen Ronayne Author Medicine - Royal Melbourne Hospital

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Grants

Awarded by Defense Advanced Research Projects Agency MTO

Awarded by Office of Naval Research Global

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by Defense Advanced Research Projects Agency MTO Contract No. N66001-12-1-4045; Office of Naval Research Global No. N62909-14-1-N020; National Health and Medical Research Council of Australia Project Grant APP1062532 and Development Grant APP1075117. This research was undertaken, in part, on the Medical Imaging Beamline at the Australian Synchrotron, VIC, Australia. Asterisk indicates corresponding author.