Journal article

Is cell migration or proliferation dominant in the formation of linear arrays of oligodendrocytes?

DM Walsh, PT Roth, WR Holmes, KA Landman, TD Merson, BD Hughes

Journal of Theoretical Biology | Elsevier | Published : 2016

Abstract

Oligodendrocytes are the myelin-producing cells of the central nervous system that are responsible for electrically insulating axons to speed the propagation of electrical impulses. A striking feature of oligodendrocyte development within white matter is that the cell bodies of many oligodendrocyte progenitor cells become organised into discrete linear arrays of three or more cells before they differentiate into myelin-producing oligodendrocytes. These linear arrays align parallel to the direction of the axons within white matter tracts and are believed to play an important role in the co-ordination of myelination. Guided by experimental data on the abundance and composition of linear arrays..

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