Is cell migration or proliferation dominant in the formation of linear arrays of oligodendrocytes?
DM Walsh, PT Roth, WR Holmes, KA Landman, TD Merson, BD Hughes
Journal of Theoretical Biology | Elsevier | Published : 2016
Oligodendrocytes are the myelin-producing cells of the central nervous system that are responsible for electrically insulating axons to speed the propagation of electrical impulses. A striking feature of oligodendrocyte development within white matter is that the cell bodies of many oligodendrocyte progenitor cells become organised into discrete linear arrays of three or more cells before they differentiate into myelin-producing oligodendrocytes. These linear arrays align parallel to the direction of the axons within white matter tracts and are believed to play an important role in the co-ordination of myelination. Guided by experimental data on the abundance and composition of linear arrays..View full abstract
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Awarded by Australian Research Council
Awarded by NSF
This work was supported by the Australian Research Council (DP140100339), International Postgraduate Research Scholarship, Australian Postgraduate Award (PTR), and Melbourne Neuroscience Institute Interdisciplinary Seed Funding Scheme. WRH was supported by NSF grants DMS1562078 and SES1556325.