Periventricular nodular heterotopia: Detection of abnormal microanatomic fiber structures with whole-brain diffusion MR imaging tractography

Abstract

Purpose: To investigate whether it is possible in patients with periventricular nodular heterotopia (PVNH) to detect abnormal fiber projections that have only previously been reported in the histopathology literature. Materials and Methods: Whole-brain diffusion-weighted (DW) imaging data from 14 patients with bilateral PVNH and 14 age- and sex-matched healthy control subjects were prospectively acquired by using 3.0-T magnetic resonance (MR) imaging between August 1, 2008, and December 5, 2012. All participants provided written informed consent. The DW imaging data were processed to generate wholebrain constrained spherical deconvolution (CSD)-based tractography data and super-resolution tr..