Journal article

Neuroanatomical Predictors of Functional Outcome in Individuals at Ultra-High Risk for Psychosis

Renate LEP Reniers, Ashleigh Lin, Alison R Yung, Nikolaos Koutsouleris, Barnaby Nelson, Vanessa L Cropley, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis, Stephen J Wood



Most individuals at ultra-high risk (UHR) for psychosis do not transition to frank illness. Nevertheless, many have poor clinical outcomes and impaired psychosocial functioning. This study used voxel-based morphometry to investigate if baseline grey and white matter brain densities at identification as UHR were associated with functional outcome at medium- to long-term follow-up. Participants were help-seeking UHR individuals (n = 109, 54M:55F) who underwent magnetic resonance imaging at baseline; functional outcome was assessed an average of 9.2 years later. Primary analysis showed that lower baseline grey matter density, but not white matter density, in bilateral frontal and limbic areas, ..

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Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia (NHMRC) Project (grant number 209062) and Program Grants (grant numbers 350241, 566529), and by the Colonial Foundation. R.L.E.P.R. was supported by a Medical Research Council Research Grant (grant number MR/K013599/1). A.L. and V.L.C. were supported by NHMRC Early Career Fellowships (A.L.: fellowship number 1072593, V.L.C.: fellowship number 628880). A.R.Y. was supported by a NHMRC Senior Research Fellowship (fellowship number 566593). B.N. was supported by an NHMRC Clinical Career Developmental Award (award number 1027532). P.D.M. and C.P. were supported by NHMRC Senior Principal Research Fellowships (SPRF Fellowship IDs: 628386 and 1105825; P.D.M.: fellowship number 1060996; C.P.: fellowship number 628386). C.P. was furthermore supported by a NARSAD Distinguished Investigator Award (award number 18722). S.J.W. was supported by a NHMRC Clinical Career Developmental Award (award number 359223) and a NARSAD Young Investigator Award. The funding sources had no role in the study design, in the collection, analysis and interpretation of the data, in the writing of the manuscript, and in the decision to submit the manuscript for publication.