Journal article
Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity
A Caminero, HJ Galipeau, JL McCarville, CW Johnston, SP Bernier, AK Russell, J Jury, AR Herran, J Casqueiro, JA Tye-Din, MG Surette, NA Magarvey, D Schuppan, EF Verdu
Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2016
Abstract
Background & Aims Partially degraded gluten peptides from cereals trigger celiac disease (CD), an autoimmune enteropathy occurring in genetically susceptible persons. Susceptibility genes are necessary but not sufficient to induce CD, and additional environmental factors related to unfavorable alterations in the microbiota have been proposed. We investigated gluten metabolism by opportunistic pathogens and commensal duodenal bacteria and characterized the capacity of the produced peptides to activate gluten-specific T-cells from CD patients. Methods We colonized germ-free C57BL/6 mice with bacteria isolated from the small intestine of CD patients or healthy controls, selected for their in vi..
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Awarded by Canadian Celiac Association
Funding Acknowledgements
Alberto Caminero received a Canadian Association of Gastroenterology/Canadian Institutes of Health Research (CIHR) postdoctoral fellowship and a New Investigator Award by the Canadian Celiac Association. JLM received a Boris Family scholarship. Chad W. Johnston received a CIHR doctoral research award. Detlef Schuppan received a grant from the German Ministry for Research and Development (BMBF): Clinical Development of Transglutaminase Inhibitors for the Treatment of Celiac Disease. Jason A. Tye-Din and Amy K. Russell were supported by Coeliac Australia, the National Health and Medical Resarch Council Independent Research Institutes Infrastructure Support Scheme grant 361646 and Victorian State Government Operational Infrastructure Support. Elena F. Verdu holds a Canada research Chair. The work was funded by a CIHR grant MOP#142773 to Elena F. Verdu.