Journal article
Unprimed, M1 and M2 macrophages differentially interact with Porphyromonas gingivalis
RS Lam, NM O'Brien-Simpson, JA Holden, JC Lenzo, SB Fong, EC Reynolds
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Tissue macrophages are amongst the first immune cells to respond to bacteria and depending on the cytokine profile at the infection site, macrophages are primed to react to infection in different ways. Priming of naive macrophages with IFN-γ produces a classical pro-inflammatory, antibacterial M1 macrophage after TLR ligation, whereas priming with IL-4 induces an anti-inflammatory tissue-repair M2 phenotype. Previous work has shown that M1 are preferentially generated in gingival tissue following infection with P. gingivalis. However, few studies have investigated the interactions of macrophage subse..
View full abstractGrants
Awarded by Australian Government, Department of Industry, Innovation and Science
Funding Acknowledgements
Supported by the Australian Government, Department of Industry, Innovation and Science Grant ID 20080108. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.