Postpartum IGF-I and IGFBP-2 levels are prospectively associated with the development of type 2 diabetes in women with previous gestational diabetes mellitus

Abstract

Aims Women with previous gestational diabetes mellitus (GDM) are at greater risk of developing type 2 diabetes. In the general population, the insulin-like growth factor (IGF) system has been implicated in the development of type 2 diabetes. The aim of this study was to determine if circulating IGF-I, IGF-II, IGFBP-1 and IGFBP-2 levels 12 weeks following a GDM pregnancy are associated with an increased risk of developing type 2 diabetes. Methods IGF-I, IGF-II, IGFBP-1 and IGFBP-2 levels were measured in 98 normal glucose tolerant women, 12 weeks following an index GDM pregnancy using enzyme immunoassay. Women were assessed for up to 10 years for the development of overt type 2 diabetes. Resu..