Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Regulation of ribosomal gene transcription

A major feature ofcancer is accelerated cell growth and proliferation. One of the major rate-limiting processes that regulates cell growth i..

ONCOGENIC SIGNALING AND CANCER THERAPY

Central to improving the management of patients with cancer is an understanding of the molecular drivers of cancer. Based on our fundamental..

New therapies for MYC-associated cancers

This proposal will evaluate a new strategy for treating cancers associated with the cancer causing gene MYC. Globally there are more than 1 ..

Pol I and Myc driven malignacy

Synthesis of ribosomes, the cellular protein synthetic machinery, is dysregulated during cancer leading to the hypothesis that it may be cau..

A NEW APPROACH TO TARGETING CELL GROWTH FOR THE TREATMENT OF CANCER

We have made the fundamental discovery that ribosomal gene transcription is not simply a 'house keeping' process in cancer cells but is requ..

UTILISING PI3K/AKT-DEPENDENT SENESCENCE TO TREAT CANCER

AKT regulation of growth and proliferation

Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely,..