The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease
Gerwyn Morris, Michael Berk, Andre Carvalho, Javier R Caso, Yolanda Sanz, Ken Walder, Michael Maes
MOLECULAR NEUROBIOLOGY | SPRINGER | Published : 2017
There is a growing awareness that gut commensal metabolites play a major role in host physiology and indeed the pathophysiology of several illnesses. The composition of the microbiota largely determines the levels of tryptophan in the systemic circulation and hence, indirectly, the levels of serotonin in the brain. Some microbiota synthesize neurotransmitters directly, e.g., gamma-amino butyric acid, while modulating the synthesis of neurotransmitters, such as dopamine and norepinephrine, and brain-derived neurotropic factor (BDNF). The composition of the microbiota determines the levels and nature of tryptophan catabolites (TRYCATs) which in turn has profound effects on aryl hydrocarbon rec..View full abstract
Awarded by NHMRC Senior Principal Research Fellowship
MB is supported by a NHMRC Senior Principal Research Fellowship 1059660.