Journal article

PARATHYROID HORMONE-RELATED PROTEIN, ITS REGULATION OF CARTILAGE AND BONE DEVELOPMENT, AND ROLE IN TREATING BONE DISEASES

T John Martin

PHYSIOLOGICAL REVIEWS | AMER PHYSIOLOGICAL SOC | Published : 2016

Abstract

Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived hormone, it has been revealed as an important paracrine/autocrine regulator in many tissues, where its effects are context dependent. Thus its location and action in the vasculature explained decades-long observations that injection of PTH into animals rapidly lowered blood pressure by producing vasodilatation. Its roles have been specified in development and maturity in cartilage and bone as a crucial regulator of endochondral bone formation and bone remodeling, respectively. Although it shares actions with parathyroid hormone (PTH) through the use of their common receptor, PTHR1, PTHrP has other actions..

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