Journal article

MEASUREMENT OF THE END-ORGAN RESPONSES TO ALDOSTERONE IN MAN - DIVERSITY OF RESPONSE AND ITS POSSIBLE BIOLOGICAL SIGNIFICANCE

WR ADAM, FAO MENDELSOHN

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | ADIS PRESS AUSTRALASIA P/L | Published : 1979

Abstract

Summary: The renal (potassium and sodium ratios) and rectal (potential difference) response to an infusion of aldosterone were measured in 13 hypertensive subjects. The correlation between these two responses was highly significant though the magnitude of the response varied widely between subjects. The variation in response between subjects showed no correlation with the change in, or maximal plasma level of, aldosterone and was thus thought to reflect a diversity in the end‐organ response to aldosterone between subjects. Biological significance of the diversity of response is suggested by the closer correlation between aldosterone excretion and aldosterone effect when the individual's part..

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