Journal article

ENHANCEMENT BY L-DOPA OF THE RENAL ACTION OF ALDOSTERONE IN THE RAT

WR ADAM

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1979

Abstract

1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhances the renal response to aldosterone. This enhanced renal response does not appear to be due to the enhanced urinary creatinine and sodium excretion also seen with L-dopa. 3. The enhanced response to aldosterone seen in the L-dopa loaded rat is inhibited by spironolactone (an aldosterone antagonist), carbidopa (an inhibitor of the enzyme producing dopamine from L-dopa in the per..

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University of Melbourne Researchers