OPIATES INHIBIT THE DOPAMINERGIC ENHANCEMENT OF THE RENAL RESPONSE TO ALDOSTERONE IN THE RAT
WR ADAM, JA DANKS, G GOLAND
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1981
1. Both naloxone, an opiate antagonist, and levorphanol, an opiate agonist, inhibit the enhanced renal response to aldosterone produced by both l-dopa pretreatment and a high K+ diet. 2. This supports the evidence for a common mechanism of action for the enhancement of the renal response to aldosterone produced by l-dopa and a high K+ diet. Whether this mechanism is dopaminergic or opiate is uncertain. 3. The inhibition of the enhanced response, produced by l-dopa, by opiates is consistent with previous findings of displacement of 3H-dopamine from renal homogenates by opiates and supports the hypothesis that the binding sites relate to the renal response to aldosterone.