Journal article

WATER DEPLETION, NOT ORAL SODIUM LOADING, INCREASES LEVELS OF SODIUM, POTASSIUM-DEPENDENT ADENOSINE-TRIPHOSPHATASE INHIBITORS IN RAT PLASMA

RM WELLARD, WR ADAM

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 1987

Abstract

In order to define a physiological role for circulating inhibitors of sodium, potassium-dependent adenosine triphosphatase (Na+,K+-ATPase), plasma was obtained from control, water deplete, water repleted, sodium deplete and sodium loaded rats. The effect of this plasma on Na+,K+-ATPase activity, and its transport equivalent 86Rb uptake, was measured in separated guinea pig renal cortical tubules. Plasma from water deplete rats had a raised plasma osmolality and sodium concentration and a significant inhibitory effect on Na+,K+-ATPase (14%) and 86Rb uptake (24%) compared with control or water repleted rats. Inhibition of Na+,K+-ATPase and 86Rb transport was not seen with plasma from rats afte..

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