Journal article

19-NOR PROGESTERONE IS A MINERALOCORTICOID AGONIST

JW FUNDER, WR ADAM

ENDOCRINOLOGY | ENDOCRINE SOC | Published : 1981

Abstract

19-Nor progesterone (19-nor P) has previously been shown to have a approximately 3-fold higher affinity for mineralocorticoid receptors than progesterone (P), its C-19 methylated parent steroid; in contrast, 19-nor aldosterone has less than 1% the mineralocorticoid receptor affinity of aldosterone. In the present study we have compared P and 19-nor P, in terms of their mineralocorticoid activity in an adrenalectomized rat urinary K+/Na+ bioassay system. Progesterone, as previously has been shown, is a mineralocorticoid antagonist with no agonist activity. In contrast, 19-nor progesterone is a full mineralocorticoid agonist, with no discernible antagonist activity. Loss of the C19 methyl is t..

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University of Melbourne Researchers