Journal article
Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: Results of the ring studies of the international immuno-oncology biomarker working group
C Denkert, S Wienert, A Poterie, S Loibl, J Budczies, S Badve, Z Bago-Horvath, A Bane, S Bedri, J Brock, E Chmielik, M Christgen, C Colpaert, S Demaria, G Van Den Eynden, G Floris, SB Fox, D Gao, B Ingold Heppner, SR Kim Show all
Modern Pathology | NATURE PUBLISHING GROUP | Published : 2016
Abstract
Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to immune-checkpoint inhibitor therapy. Although many groups are currently evaluating TIL, there is no standardized system for diagnostic applications. This study reports the results of two ring studies investigating TIL conducted by the International Working Group on Immuno-oncology Biomarkers. The study aim was to determine the intraclass correlation coefficient (ICC) for evaluation of TIL by different pathologists. A total of 120 slides were evaluated by a large group of pathologists with a web-based system in ring study 1 and a more advan..
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Awarded by European Commission
Funding Acknowledgements
We would like to thank all patients, clinicians, and pathologists participating in the clinical studies and the biomaterial collection. We are grateful for the excellent technical assistance by Britta Beyer, Sylwia Handzik, Ines Koch, Petra Wachs as well as Peggy Wolkenstein. Funding was given by the European Commission FP7, Grant 278659 (RESPONSIFY) and the TRANSCAN-I, Grant BMBF-01KT1314 (TRANSCAN-I UGI 1).