Journal article

Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria

Sarah Potter, Tailoi Chan-Ling, Helen J Ball, Hussein Mansour, Andrew Mitchell, Linda Maluish, Nicholas H Hunt

International journal for parasitology | ELSEVIER SCI LTD | Published : 2006


Cerebral malaria is a serious complication of Plasmodium falciparum infection. We have investigated the role of perforin in the pathogenesis of cerebral malaria in a murine model (Plasmodium berghei ANKA (PbA) infection). C57BL/6 mice demonstrated the typical neuropathological symptoms of experimental cerebral malaria infection from day 5p.i. and became moribund on day 6p.i. This pathology was not seen in PbA-infected, perforin-deficient (pfp-/-) mice. From days 5-6p.i. onwards there was a significant increase in mRNA for granzyme B and CD8, but not CD4, in brain tissue from PbA-infected C57BL/6 and pfp-/- mouse brains. Perforin mRNA was strongly increased in the brains of PbA-infected C57BL..

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University of Melbourne Researchers