Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice
Leia Hee, Anuwat Dinudom, Andrew J Mitchell, Georges E Grau, David I Cook, Nicholas H Hunt, Helen J Ball
International Journal for Parasitology | ELSEVIER SCI LTD | Published : 2011
Lung complications during malaria infection can range from coughs and impairments in gas transfer to the development of acute respiratory distress syndrome (ARDS). Infecting C57BL/6 mice with Plasmodium berghei K173 strain (PbK) resulted in pulmonary oedema, capillaries congested with leukocytes and infected red blood cells (iRBCs), and leukocyte infiltration into the lungs. This new model of malaria-associated lung pathology, without any accompanying cerebral complications, allows the investigation of mechanisms leading to the lung disease. The activity of the amiloride-sensitive epithelial sodium channel (ENaC) in alveolar epithelial cells is decreased by several respiratory tract pathogen..View full abstract
This study was supported by a grant from the Australian National Health and Medical Research Council to N.H., H.B. and G.E.G. L.H. received a PhD scholarship from Australian Rotary Health. We thank Meichien Say, Jane Radford and Valery Combes (University of Sydney. Australia) for their assistance with the immunohistochemical analysis.