Journal article

A role for the hepatobiliary system in IgE-mediated intestinal inflammation in the rat

AM Collins, S Leach, JPA Mitchell, Y Dai, GDF Jackson

CLINICAL AND EXPERIMENTAL ALLERGY | WILEY-BLACKWELL | Published : 1999

Abstract

BACKGROUND: For many years the central focus of research into gastrointestinal hypersensitivity reactions has been the mast cell population of the intestinal lamina propria. Since bile is known to deliver immunological mediators to the gastrointestinal tract, the possibility arises that extra-intestinal populations of mast cells may also contribute to IgE-mediated intestinal damage. OBJECTIVES: To characterize hepatic mast cells in the rat and to investigate the role of the hepatobiliary system in a model of IgE-mediated reactivity to dietary antigen. METHODS: Wistar rats were passively sensitized with monoclonal antidinitrophenyl (DNP) IgE antibodies, and were later challenged orogastricall..

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University of Melbourne Researchers