Adverse effects in epilepsy: Recognition, measurement, and taxonomy

Abstract

The goal of balancing adverse the side effects of a medication with its efficacy for seizures has been a primary topic in the epilepsy community since the discussion of bromide therapy by Sieveking and Locock at a meeting of the Royal Medical Society in London in 1857. The conventional means of identifying adverse medication effects has been direct questioning of the patient in the clinic setting. Several instruments have been developed to assess seizure medication adverse effects in a reliable and valid manner. Medication side effects have typically been presented in clinical studies as lists of symptoms or medical problems. The combination of medication side effects and comorbid mood disor..