Changes in sex steroid levels in women with epilepsy on treatment: Relationship with antiepileptic therapies and seizure frequency
Carlo Andrea Galimberti, Flavia Magri, Francesco Copello, Carla Arbasino, Spyridon Chytiris, Massimo Casu, Pietro Ameri, Piero Perucca, Giovanni Murialdo
EPILEPSIA | WILEY-BLACKWELL PUBLISHING, INC | Published : 2009
PURPOSE: Reproductive dysfunction in epilepsy is attributed to the seizures themselves and also to antiepileptic drugs (AEDs), which affect steroid production, binding, and metabolism. In turn, neuroactive steroids may influence neuronal excitability. A previous study in this cohort of consecutive women with epilepsy showed that patients with more frequent seizures had higher cortisol and lower dehydroepiandrosterone sulfate levels than those with rare or absent seizures. The present study was aimed at evaluating, in these same women, the possible relationship between some clinical parameters, seizure frequency, AED therapies, and sex hormone levels. METHODS: Estradiol (E2), progesterone (Pg..View full abstract
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