Pharmacokinetic and clinical evaluation of liquid L-dopa/carbidopa in Parkinson's disease

Abstract

The aim of the study was to assess the pharmacokinetic properties and clinical effectiveness of L-dopa/carbidopa solution treatment in patients with parkinsonian motor fluctuations. No significant difference in maximal L-dopa concentration, time to peak L-dopa concentration and area under curve was found in single dose studies which compared equivalent tablet and solution L-dopa/carbidopa doses in 9 patients. Seven out of 10 patients treated with hourly doses of liquid L-dopa/carbidopa were improved after switching from conventional tablet medication. Less Off time per day and less Off phase disability were the usual benefits. Six of these patients maintained this improvement and continued o..