SK channel function regulates the dopamine phenotype of neurons in the substantia nigra pars compacta
TD Aumann, I Gantois, K Egan, A Vais, D Tomas, J Drago, MK Horne
EXPERIMENTAL NEUROLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008
Parkinson's disease (PD) is characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). It is widely believed that replacing lost SNc DA neurons is a key to longer-term effective treatment of PD motor symptoms, but generating new SNc DA neurons in PD patients has proven difficult. Following loss of tyrosine hydroxylase-positive (TH+) SNc neurons in the rodent 6-hydroxy-DA (6-OHDA) model of PD, the number of TH+ neurons partially recovers and there is evidence this occurs via phenotype "shift" from TH- to TH+ cells. Understanding how this putative phenotype shift occurs may help increase SNc DAergic neurons in PD patients. In this study we characterize..View full abstract
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Awarded by The National Health and Medical Research Council (NHMRC) of Australia
The National Health and Medical Research Council (NHMRC) of Australia Program Grant #236805 supported this study. TA is a Neurosciences Victoria Fellow. JD is an NHMRC Practitioner Fellow. The authors thank Dr Steve Petrou for use of his vibratome throughout these experiments.