Low versus high dialysate calcium concentration in alternate night nocturnal hemodialysis: A randomized controlled trial
Rosemary Masterson, Susan Blair, Kevan R Polkinghorne, Kenneth K Lau, Michael Lian, Boyd J Strauss, John G Morgan, Peter Kerr, Nigel D Toussaint
HEMODIALYSIS INTERNATIONAL | WILEY | Published : 2017
INTRODUCTION: Higher calcium dialysate is recommended for quotidian nocturnal hemodialysis (NHD) (≥6 nights/week) to maintain bone health. It is unclear what the optimal calcium dialysate concentration should be for alternate night NHD. We aimed to determine the effect of low calcium (LC) versus high calcium (HC) dialysate on cardiovascular and bone parameters in this population. METHODS: A randomized controlled trial where participants were randomized to LC (1.3 mmol/L, n = 24) or HC dialysate (1.6 or 1.75 mmol/L, n = 26). Primary outcome was change in mineral metabolism markers. Secondary outcomes included change in vascular calcification (VC) scores [CT abdominal aorta (AA) and superficia..View full abstract
This study was supported by an educational grant from Roche Pharmaceuticals.