Journal article
Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module
U Ackermann, JS Lewis, K Young, MJ Morris, A Weickhardt, ID Davis, AM Scott
Journal of Labelled Compounds and Radiopharmaceuticals | WILEY-BLACKWELL | Published : 2016
DOI: 10.1002/jlcr.3417
Abstract
Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [18F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of ..
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Awarded by National Cancer Institute
Funding Acknowledgements
The authors acknowledge financial support from the Movember Foundation and NIH grant P30 CA08748, which supported, in part, the Organic Synthesis Core and the Radiochemistry & Molecular Imaging Probe Core at Memorial Sloan Kettering Cancer Center for the FDHT precursor and standard. IDD is an NHMRC Practitioner Fellow (APP1102604).