Journal article

The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013

Jeffrey D Stanaway, Abraham D Flaxman, Mohsen Naghavi, Christina Fitzmaurice, Theo Vos, Ibrahim Abubakar, Laith J Abu-Raddad, Reza Assadi, Neeraj Bhala, Benjamin Cowie, Mohammad H Forouzanfour, Justina Groeger, Khayriyyah Mohd Hanafiah, Kathryn H Jacobsen, Spencer L James, Jennifer MacLachlan, Reza Malekzadeh, Natasha K Martin, Ali A Mokdad, Ali H Mokdad Show all

The Lancet | ELSEVIER SCIENCE INC | Published : 2016

Abstract

BACKGROUND: With recent improvements in vaccines and treatments against viral hepatitis, an improved understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We used data from the Global Burden of Disease (GBD) Study to estimate morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer caused by viral hepatitis, by age, sex, and country from 1990 to 2013. METHODS: We estimated mortality using natural history models for acute hepatitis infections and GBD's cause-of-death ensemble model for cirrhosis and liver cancer. We used meta-regression to estimate total cirrhosis and total liver cancer prevalence, as well as the propor..

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Grants

Awarded by US National Institute on Drug Abuse


Awarded by US National Institutes of Health (NIH) - NIH: National Institute of Allergy and Infectious Diseases


Awarded by UK Medical Research Council


Awarded by NIH


Awarded by Qatar National Research Fund


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE ON DRUG ABUSE


Funding Acknowledgements

Bill & Melinda Gates Foundation.JDS, ADF, MN, CF, TV, MHF, and CJLM acknowledge research funding from the Bill & Melinda Gates Foundation. NKM acknowledges research funding from the US National Institute on Drug Abuse (R01 DA037773-01A1) and the University of California San Diego Center for AIDS Research, a programme funded by the US National Institutes of Health (NIH; P30 AI036214), which is supported by the following NIH Institutes and Centers: National Institute of Allergy and Infectious Diseases, National Cancer Institute, National Institute of Mental Health, National Institute on Drug Abuse, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Heart, Lung, and Blood Institute, National Institute on Aging, National Institute of General Medical Sciences, and National Institute of Diabetes and Digestive and Kidney Diseases. NKM is also a member of the STOP-HCV consortium, which is funded by the UK Medical Research Council (MR/K01532X/1). CF acknowledges funding from the NIH (5T32HL007093-40). LJA acknowledges the support of the Qatar National Research Fund (NPRP 04-924-3-251), which provided the main funding for generating the data that LJA-R contributed to the Global Burden of Disease Study. GC is supported in part by the Biomedical Research Centre of Imperial College National Health Service (NHS) Trust and Medical Research Council STOP-HCV consortium. There was no specific funding for this project. The views expressed are those of the authors and not necessarily those of the UK NHS, UK National Institute for Health Research, US Centers for Disease Control and Prevention, or the UK Department of Health.