Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase

Jitendra R Harjani; Beow Keat Yap; Eleanor WW Leung; Andrew Lucke; Sandra E Nicholson; Martin J Scanlon; David K Chalmers; Philip E Thompson; Raymond S Norton; Jonathan B Baell

Journal article

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase

Jitendra R Harjani, Beow Keat Yap, Eleanor WW Leung, Andrew Lucke, Sandra E Nicholson, Martin J Scanlon, David K Chalmers, Philip E Thompson, Raymond S Norton, Jonathan B Baell

Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2016

DOI: 10.1021/acs.jmedchem.6b00386

University of Melbourne Researchers

Sandra Nicholson Author Medical Biology (W.E.H.I.)

Grants

Awarded by NHMRC

Awarded by NHMRC Independent Research Institute Infrastructure Support (IRIISS)

Funding Acknowledgements

We thank Kade Roberts for helpful discussions. B.K.Y. is the recipient of an Academic Staff Training Scheme Fellowship of Universiti Sains Malaysia. R.S.N. and J.B.B. acknowledge Fellowship support from the National Health and Medical Research Council of Australia (NHMRC). This study was supported by NHMRC research grants 1016647 and 1022693, as well as NHMRC Independent Research Institute Infrastructure Support (IRIISS) grant 361646 and a Victorian State Government Operational Infrastructure Scheme grant.