Analysis of maternal–fetal heart rate coupling directions with partial directed coherence

Abstract

Maternal psycho-physiological activities affect the fetal heart rate and heart rate variability. However, directions and patterns of maternal and fetal heartbeat coupling are still poorly understood. The aim of this study was to quantify the direction of short-term maternal–fetal cardiac coupling in early, mid and late gestation fetuses by using partial directed coherence (PDC) analysis approach. The analysis was based on fetal electrocardiograms (fECGs) of 66 healthy fetuses; 22 from early gestation 16–25 weeks, 22 from mid gestation 26–30 weeks and 22 from late gestation 32–41 weeks. Results of analyzing PDC demonstrated a causal influence of fetal on maternal heart rate in the early gesta..