Journal article
Global dissemination of a multidrug resistant Escherichia coli clone
NK Petty, NLB Zakour, M Stanton-Cook, E Skippington, M Totsika, BM Forde, MD Phan, DG Moriel, KM Peters, M Davies, BA Rogers, G Dougan, J Rodriguez-Baño, A Pascual, JDD Pitout, M Upton, DL Paterson, TR Walsh, MA Schembri, SA Beatson
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2014
Abstract
Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000-2011. The global phylogen..
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Awarded by Medical Research Council
Funding Acknowledgements
We thank Deborah Williamson, Karina Kennedy, and Hanna Sidjabat for their contribution of strains. We thank the Wellcome Trust Sanger Institute and Australian Genome Research Facility for sequencing. This work was supported by Australian National Health and Medical Research Council (NHMRC) Grants APP1012076 and APP1067455 (to M. A. S. and S. A. B.). N.K.P. and E. S. were supported by the Australian Infectious Diseases Research Centre. M. A. S. is supported by Australian Research Council (ARC) Future Fellowship FT100100662. M. T. is supported by ARC Discovery Early Career Researcher Award DE130101169. M. D. is supported by NHMRC Training Fellowship GNT0635250. J.R.-B. and A. P. are supported by the Ministerio de Economia y Competitividad, Instituto de Salud Carlos III, the Spanish Network for Research in Infectious Diseases RD12/0015; Fondo de Investigacion Sanitaria Grants 070190, 10/02021, 10/0195, and 10/00795; and Junta de Andalucia Grants 0048/2008 and CTS-5259.