Soluble flagellin, FliC, induces an Ag-specific Th2 response, yet promotes T-bet-regulated Th1 clearance of Salmonella typhimurium infection
Saeeda Bobat, Adriana Flores-Langarica, Jessica Hitchcock, Jennifer L Marshall, Robert A Kingsley, Margaret Goodall, Cristina Gil-Cruz, Karine Serre, Denisse L Leyton, Shirdi E Letran, Fabrina Gaspal, Rebecca Chester, Jayne L Chamberlain, Gordon Dougan, Constantino Lopez-Macias, Ian R Henderson, James Alexander, Ian CM MacLennan, Adam F Cunningham
European Journal of Immunology | WILEY-BLACKWELL | Published : 2011
Awarded by National Council for Science and Technology (CONACYT)
Awarded by Biotechnology and Biological Sciences Research Council
Awarded by Medical Research Council
The authors are grateful to the Birmingham Medical Sciences Unit for their expert assistance and to Dr. Alison O'Brien (Uniformed Services University of the Health Sciences) for supplying the flagellin phase-locked mutants from which the mutant strains used here were derived. This work was funded by a Biotechnology and Biological Sciences Research Council New Investigator Award to A. F. C.; S. B. was the recipient of a Medical Research Council studentship; C. G.-C and C. L.-M are funded by National Council for Science and Technology (CONACYT) grants: SEP-2003-CO2-45261, SALUD 2004-01-132, and SALUD-2007-C01-69779.