Journal article
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
NR Thomson, DJ Clayton, D Windhorst, G Vernikos, S Davidson, C Churcher, MA Quail, M Stevens, MA Jones, M Watson, A Barron, A Layton, D Pickard, RA Kingsley, A Bignell, L Clark, B Harris, D Ormond, Z Abdellah, K Brooks Show all
Genome Research | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2008
Open access
Abstract
We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host a..
View full abstractGrants
Funding Acknowledgements
We thank the core sequencing and informatics teams at the Sanger Institute for their assistance and The Wellcome Trust for its support of the Sanger Institute Pathogen Sequencing Unit. This project was funded through The Wellcome Trust Beowulf Genomics Initiative.