Journal article
Metal–Organic Framework Coatings as Cytoprotective Exoskeletons for Living Cells
K Liang, JJ Richardson, J Cui, F Caruso, CJ Doonan, P Falcaro
Advanced Materials | WILEY-V C H VERLAG GMBH | Published : 2016
Abstract
The biomimetic mineralization of metal-organic framework (MOF) material on living cells is reported. ZIF-8 can be crystallized on a living cell surface as an exoskeleton that offers physical protection while allowing transport of essential nutrients, thus maintaining cell viability. The MOF shell prevents cell division, leading to an artificially induced pseudo-hibernation state. Cellular functions can be fully restored upon MOF removal.
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
K.L. and J.J.R. acknowledge CSIRO OCE Science Scheme and Manufacturing FST SPG grant. This work was supported by the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036) and performed in part at the Materials Characterization and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Part of this research was conducted at the SAXS/WAXS beamline at the Australian Synchrotron.