Journal article

The distribution of muscarinic M1 receptors in the human hippocampus

Elizabeth Scarr, Myoung Suk Seo, Timothy Douglas Aumann, Gursharan Chana, Ian Paul Everall, Brian Dean

JOURNAL OF CHEMICAL NEUROANATOMY | ELSEVIER SCIENCE BV | Published : 2016

Abstract

The muscarinic M1 receptor plays a significant role in cognition, probably by modulating information processing in key regions such as the hippocampus. To understand how the muscarinic M1 receptor achieves these functions in the hippocampus, it is critical to know the distribution of the receptor within this complex brain region. To date, there are limited data on the distribution of muscarinic M1 receptors in the human hippocampus which may also be confounded because some anti-muscarinic receptor antibodies have been shown to lack specificity. Initially, using Western blotting and immunohistochemistry, we showed the anti-muscarinic M1 receptor antibody to be used in our study bound to a sin..

View full abstract

Grants

Awarded by NHMRC


Awarded by ARC


Funding Acknowledgements

The authors thank Geoff Pavey for his curation of the human post-mortem tissue and Doris Tomas for her technical assistance. Tissues were received from the Victorian Brain Bank Network, supported by The Florey Institute of Neuroscience and Mental Health, The Alfred and the Victorian Forensic Institute of Medicine and funded in part by Australia's National Health & Medical Research Council, Parkinson's Victoria and MND Victoria. This study was also supported by Operational Infrastructure Support (OIS) from the Victorian State Government. NHMRC; Grant numbers: APP1045619, APP1002240 & APP1037234. ARC; Grant numbers: FT100100689 & DP110100086.