Journal article

alpha(1)-Acid glycoprotein as a putative biomarker for monitoring the development of the type II reactional stage of leprosy

Nishma Gupta, Nallakandy P Shankernarayan, Kuppamuthu Dharmalingam



Leprosy, a spectral disease manifested on the basis of host immune responses, is complicated by its reactional stages, namely type I reversal reaction (RR) and type II erythema nodosum leprosum (ENL). These reactional stages are characterized by uncontrolled and aberrant immune responses. Biomarkers for reactional stages would aid in early diagnosis, efficient treatment, prevention of neurological complications and prediction of predisposition to reactional stages. In this study, comparative analysis of the serum proteome of leprosy patients by two-dimensional electrophoresis (2DE) followed by mass spectrometry showed differential expression of acute-phase protein alpha (1)-acid glycoprotein..

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University of Melbourne Researchers


Awarded by Department of Biotechnology, New Delhi, India

Awarded by Indian Council of Medical Research

Awarded by University Grants Commission, Government of India

Funding Acknowledgements

K. D. thanks the Department of Biotechnology, New Delhi, India, for grant CGSEM/BT/03/002/87-Vol. IV and BT/PR6937/MED/14/905/2005 and the Indian Council of Medical Research for grant 63/21/002-BMS. The financial support from the University Grants Commission, Government of India, under the programme Centre of Potential in the Subject of Genomic Sciences, School of Biotechnology, F.1-41/2001 (CPP2), is acknowledged. N. G. was a recipient of a Senior Research Fellowship from the Council of Scientific and Industrial Research, New Delhi, India. We thank Rachel Martin, Matt Openshaw and H. R. Prashanth for their help in mass spectrometry.