Journal article

Serum proteome of leprosy patients undergoing erythema nodosum leprosum reaction: Regulation of expression of the lsoforms of haptoglobin

Nishma Gupta, Nallakandy P Shankernarayan, Kuppamuthu Dharmalingam

JOURNAL OF PROTEOME RESEARCH | AMER CHEMICAL SOC | Published : 2007

Abstract

Validated proteome profile allows better understanding of disease progression, subtype classification, susceptibility patterns, and disease prognosis. Leprosy is a spectral disease, with clinically, histologically, immunologically, and bacteriologically distinguishable subtypes. In addition, a significant fraction of patients undergo immune mediated reactions even after multidrug therapy (MDT). Erythema nodosum leprosum (ENL) is an immune complex mediated reactional condition in leprosy, characterized by a systemic inflammatory condition afflicting borderline lepromatous (BL) and lepromatous leprosy patients (LL). In this study, we have analyzed serum proteome of leprosy patients undergoing ..

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University of Melbourne Researchers