Journal article
The prognostic value of TP53 mutations in oesophageal adenocarcinoma: A systematic review and meta-analysis
OM Fisher, SJ Lord, D Falkenback, NJ Clemons, GD Eslick, RV Lord
Gut | Published : 2017
Open access
Abstract
Objective To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. Design A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect to identify studies published between January 1990 and February 2015 of oesophageal cancer populations (with OAC diagnoses >50% of cases) that measured tumoural TP53 status and reported hazard ratios (HR), or adequate data for estimation of HR for survival for TP53-defined subgroups. Risk of bias for HR estimates was assessed using prespecified criteria for the appraisal of rel..
View full abstractGrants
Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
This work was supported by the Progression of Barrett's Esophagus Network (PROBE-Net, Chief Investigator David C. Whiteman) and by the Australian National Health and Medical Research Council (NHMRC 1040947), Cancer Council New South Wales (SRP 08-04 and RG 13-03) and St Vincent's Clinic Foundation, Sydney.