Journal article
A comprehensive evaluation of myocardial fibrosis in hypertrophic cardio myopathy with cardiacmagnetic resonance imaging: Linking genotype with fibrotic phenotype
AH Ellims, LM Iles, LH Ling, B Chong, I Macciocca, GS Slavin, JL Hare, DM Kaye, SF Marasco, CA McLean, PA James, D Du Sart, AJ Taylor
European Heart Journal Cardiovascular Imaging | OXFORD UNIV PRESS | Published : 2014
DOI: 10.1093/ehjci/jeu077
Abstract
Aims In hypertrophic cardio myopathy (HCM), attempts to associate genotype with phenotype have largely been unsuccessful. More recently, cardiac magnetic resonance(CMR)imaging has enhancedmyocardial fibrosis characterization, while nextgeneration sequencing (NGS) can identify pathogenic HCM mutations. We used CMR and NGS to explore the link between genotype and fibrotic phenotype in HCM. Methods and results Onehund red and thirty-nine patients with HCM and 25 healthy control sunder went CMR to quantify regional myocardial fibrosis with late gadolinium enhancement (LGE) and diffuse myocardial fibrosis with post-contrast T1 mapping.Collagen content of myecto my specimens from nine HCM patients..
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Funding Acknowledgements
A.H.E. is supported by a combined Heart Foundation of Australia and National Heart and Medical Research Council Postgraduate Research Scholarship, Melbourne, Australia. L.M.I. is supported by a National Health and Medical Research Council Postgraduate Research Scholarship, Melbourne, Australia. J.L.H. is supported by a Cardiac Society of Australia and New Zealand Research Investigatorship. D.M.K. is supported by a National Health and Medical Research Council program grant. A.J.T. is supported by a National Health and Medical Research Council project grant. The study was supported by a Centre of Research Excellence Grant from the National Health and Medical Research Council of Australia.