Mature B-cell leukemias

Abstract

Introduction The mature B-cell leukemias are a pathologically diverse group of diseases that share commonalities in clinical presentation and behavior. Early stage patients are often diagnosed incidentally on a routine complete blood count and blood film, whereas advanced stage patients present with lymphadenopathy, organomegaly, bone marrow infiltration and cytopenias. All of these leukemias are considered “indolent” in that they tend to progress relatively slowly (over months to years), and all are currently incurable with conventional therapy but are often exquisitely sensitive to the graft-versus-leukemia effect of allogeneic stem cell transplantation. Precise classification of mature B-..