Journal article

Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions

Marie Levade, Elodie David, Cedric Garcia, Pierre-Alexandre Laurent, Sarah Cadot, Anne-Sophie Michallet, Jean-Claude Bordet, Constantine Tam, Pierre Sie, Loic Ysebaert, Bernard Payrastre

Blood | AMER SOC HEMATOLOGY | Published : 2014

Abstract

The oral Bruton's tyrosine kinase inhibitor, ibrutinib, has recently demonstrated high efficiency in patients with relapsed B-cell malignancies. Occurrence of bleeding events has been reported in a subgroup of ibrutinib-treated patients. We demonstrate that ibrutinib selectively inhibits platelet signaling and functions downstream of the collagen receptor glycoprotein VI and strongly affects firm platelet adhesion on von Willebrand factor (VWF) under arterial flow. A longitudinal study of 14 patients indicated a correlation between occurrence of bleeding events and decreased platelet aggregation in response to collagen in platelet-rich plasma and firm adhesion on VWF under arterial flow. The..

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