Autologous and allogeneic stem cell transplantation: Rising therapeutic promise for mantle cell lymphoma

Abstract

Mantle cell lymphoma (MCL) is currently an incurable neoplasm with a median survival duration of 3-5 years. The clinical results of therapy with cyclophosphamide, doxorubicin, vincristine, and prednisone or similar regimens are inadequate, leading to widespread exploration of the use of autologous stem cell transplantation (ASCT) during the first remission. In the pre-rituximab era, early ASCT extended the median remission duration by 1-2 years, but most patients eventually experienced relapse. With the advent of rituximab and its incorporation into stem cell mobilization and conditioning regimens, several research groups have reported improved outcomes, including the emergence of early surv..