Journal article
Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis
HB Forrester, J Li, T Leong, MJ McKay, CN Sprung
Radiotherapy and Oncology | ELSEVIER IRELAND LTD | Published : 2014
Abstract
Background and purpose During radiotherapy, normal tissue is unavoidably exposed to radiation which results in severe normal tissue reactions in a small fraction of patients. Because those who are sensitive cannot be determined prior to radiotherapy, the doses are limited to all patients to avoid an unacceptable number of severe adverse normal tissue responses. This limitation restricts the optimal treatment for individuals who are more tolerant to radiation. Genetic variation is a likely source for the normal tissue radiosensitivity variation observed between individuals. Therefore, understanding the radiation response at the genomic level may provide knowledge to develop individualized tre..
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Awarded by National Institutes of Health
Funding Acknowledgements
This Project was supported through the 2010 round of the priority-driven Collaborative Cancer Research Scheme (Grant 1002743) and funded by the Australian Government Department of Health and Ageing with the assistance of Cancer Australia. Also, this work was supported by the Australian National Health and Medical Research Council [Grant Numbers 145780, 288713; http://www.nhmrc.gov.au/]; the Australian National Breast Cancer Foundation [Grant PG-08-06; http://www.nbcf.org.au/]; and the National Institute of Health (Grant 5U19AI067773-07). Support was also provided by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.