Journal article
Des-acyl ghrelin inhibits the capacity of macrophages to stimulate the expression of aromatase in breast adipose stromal cells
CMC Au, MM Docanto, H Zahid, FM Raffaelli, RL Ferrero, JB Furness, KA Brown
Journal of Steroid Biochemistry and Molecular Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
Des-acyl ghrelin is the unacylated form of the well-characterized appetite-stimulating hormone ghrelin. It affects a number of physiological processes, including increasing adipose lipid accumulation and inhibiting adipose tissue inflammation. Breast adipose tissue inflammation in obesity is associated with an increase in the expression of the estrogen biosynthetic enzyme, aromatase, and is hypothesized to create a hormonal milieu conducive to tumor growth. We previously reported that des-acyl ghrelin inhibits the expression and activity of aromatase in isolated human adipose stromal cells (ASCs), the main site of aromatase expression in the adipose tissue. The current study aimed to examine..
View full abstractGrants
Awarded by National Breast Cancer Foundation
Awarded by NHMRC (Australia) Career Development Award
Awarded by Senior Research Fellowship
Awarded by NHMRC
Funding Acknowledgements
This work was supported by a grant from the National Breast Cancer Foundation (NC-14-011), and by the Victorian Government Operational Infrastructure Support Program. CCA is supported by an Endocrine Society of Australia Research Higher Degree Scholarship. KAB was supported by an NHMRC (Australia) Career Development Award GNT1007714, the Endocrine Society of Australia Ken Wynne Memorial Postdoctoral Research Award, and by the Mavis Robertson Fellowship from the National Breast Cancer Foundation (ECF-16-004). RLF is supported by a Senior Research Fellowship (APP1079904) and project grants (APP1079930, APP1107930) from the NHMRC.