Journal article

Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population

I Russel Lee, James S Molton, Kelly L Wyres, Claire Gorrie, Jocelyn Wong, Chu Han Hoh, Jeanette Teo, Shirin Kalimuddin, David C Lye, Sophia Archuleta, Kathryn E Holt, Yunn-Hwen Gan

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2016

Grants

Awarded by National Medical Research Council of Singapore


Awarded by Singapore Infectious Diseases Initiative


Awarded by National Health and Medical Research Council of Australia


Awarded by Victorian Life Sciences Computation Initiative


Awarded by National University of Singapore, Yong Loo Lin School of Medicine Aspiration Fund


Funding Acknowledgements

We thank the A-KLASS study team including all research assistants, as well as staff of the Singapore Clinical Research Network and Singapore Infectious Diseases Initiative for their support of this work. We also thank Tse Hsien Koh for critical comments and reading of the manuscript. We are grateful to the team of curators of the Institut Pasteur MLST and whole-genome MLST databases for curating the data and making them publicly available at http://bigsdb.web.pasteur.fr/. The A-KLASS clinical trial was funded by National Medical Research Council of Singapore (NMRC/CNIG/1101/2013) and Singapore Infectious Diseases Initiative (SIDI/2013/006). The genome analysis was funded by National Health and Medical Research Council of Australia (grants #1043822 and #1061409 to K.E.H.) and Victorian Life Sciences Computation Initiative (grant #VR0082). All other aspects of the work were supported by National University of Singapore, Yong Loo Lin School of Medicine Aspiration Fund (NUHSRO/2014/068/AF-New Idea/03 to Y.H.G.). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.