Journal article
Differential host susceptibility and bacterial virulence factors driving Klebsiella liver abscess in an ethnically diverse population
IR Lee, JS Molton, KL Wyres, C Gorrie, J Wong, CH Hoh, J Teo, S Kalimuddin, DC Lye, S Archuleta, KE Holt, YH Gan
Scientific Reports | NATURE PORTFOLIO | Published : 2016
DOI: 10.1038/srep29316
Abstract
Hypervirulent Klebsiella pneumoniae is an emerging cause of community-acquired pyogenic liver abscess. First described in Asia, it is now increasingly recognized in Western countries, commonly afflicting those with Asian descent. This raises the question of genetic predisposition versus geospecific strain acquisition. We leveraged on the Antibiotics for Klebsiella Liver Abscess Syndrome Study (A-KLASS) clinical trial ongoing in ethnically diverse Singapore, to prospectively examine the profiles of 70 patients together with their isolates' genotypic and phenotypic characteristics. The majority of isolates belonged to capsule type K1, a genetically homogenous group corresponding to sequence-ty..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank the A-KLASS study team including all research assistants, as well as staff of the Singapore Clinical Research Network and Singapore Infectious Diseases Initiative for their support of this work. We also thank Tse Hsien Koh for critical comments and reading of the manuscript. We are grateful to the team of curators of the Institut Pasteur MLST and whole-genome MLST databases for curating the data and making them publicly available at http://bigsdb.web.pasteur.fr/. The A-KLASS clinical trial was funded by National Medical Research Council of Singapore (NMRC/CNIG/1101/2013) and Singapore Infectious Diseases Initiative (SIDI/2013/006). The genome analysis was funded by National Health and Medical Research Council of Australia (grants #1043822 and #1061409 to K.E.H.) and Victorian Life Sciences Computation Initiative (grant #VR0082). All other aspects of the work were supported by National University of Singapore, Yong Loo Lin School of Medicine Aspiration Fund (NUHSRO/2014/068/AF-New Idea/03 to Y.H.G.). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.