Journal article

Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial

Jacqueline F Gould, Karli Treyvaud, Lisa N Yelland, Peter J Anderson, Lisa G Smithers, Robert A Gibson, Andrew J McPhee, Maria Makrides

BMJ OPEN | BMJ PUBLISHING GROUP | Published : 2016

Abstract

INTRODUCTION: Despite recommendations that pregnant women increase their docosahexaenoic acid (DHA) intake to support fetal brain development, a recent systematic review found a lack of high-quality data to support the long-term effects of DHA supplementation on children's neurodevelopment. METHODS AND ANALYSIS: We will assess child neurodevelopment at 7 years of age in follow-up of a multicentre double-blind randomised controlled trial of DHA supplementation in pregnancy. In 2010-2012, n=2399 Australian women with a singleton pregnancy <21 weeks' gestation were randomised to receive 3 capsules daily containing a total dose of 800 mg DHA/day or a vegetable oil placebo until birth. N=726 chil..

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